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KMID : 0380020130280020074
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Korean Journal of Biotechnology and Bioengineering
2013 Volume.28 No. 2 p.74 ~ p.79
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Antifungal Activities of Hemistepsin A and B Isolated from Hemistepita lyrata Bunge against Dandruff-causing Microbe Malassezia obutusa
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Lee Jong-Rok
Jung Dae-Hwa
Park Moon-Ki
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Abstract
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There are a large number of bioactive sesquiterpene lactones from compositae plants including Hemistepita lyrata Bunge. In the present study, we purified two sesquiterpene lactones, Hemistepsin A and B, from H. lyrata and evaluated their antimicrobial activities against Malassezia obutusa. Chromatographic separation was used for the preparation of Hemistepsin A and B, and the identity of these compounds was confirmed by NMR. Strong inhibition of growth of M. obutusa was obtained with all doses of Hemistepsin A tested. Moreover, antifungal activity of Hemistepsin A occurred in a dose-dependent manner. Hemistepsin B also showed potent antifungal activity at the dose of 800 μm/dis. From these results, it was suggested that Hemistepsin A and B be beneficial for the preparation of the useful agent for treating scalp diseases occurred by dandruff-causing Malassezia species.
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KEYWORD
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Hemistepsin A, Hemistepsin B, Antifungal Activity, Dandruff, Hemistepita lyrata
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